Combined immunization with SARS-CoV-2 spike and SARS-CoV nucleocapsid protects K18-hACE2 mice but increases lung pathology

Abstract Vaccines against SARS-CoV-2 have targeted the spike protein and have been successful at preventing disease. However, with the emergence of variants, spike-specific vaccines become less effective. The nucleocapsid protein is relatively conserved among variants of SARS-CoV-2 and is a candidat...

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Hlavní autoři:	Jaekwan Kim, Alla Kachko, Prabhuanand Selvaraj, David Rotstein, Charles Brandon Stauft, Naveen Rajasagi, Yangqing Zhao, Tony Wang, Marian Major
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-02-01
Edice:	npj Vaccines
On-line přístup:	https://doi.org/10.1038/s41541-025-01085-1
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