Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

Abstract Background Clearance at the blood-brain barrier (BBB) plays an important role in removal of Alzheimer’s amyloid-β (Aβ) toxin from brain both in humans and animal models. Apolipoprotein E (apoE), the major genetic risk factor for AD, disrupts Aβ clearance at the BBB. The cellular and molecul...

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Главные авторы:	Qingyi Ma, Zhen Zhao, Abhay P Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B Verghese, Joachim Herz, David M Holtzman, Berislav V Zlokovic
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2018-10-01
Серии:	Molecular Neurodegeneration
Предметы:	Pericyte Blood-brain barrier (BBB) Amyloid-β clearance Low-density lipoprotein receptor-related protein 1 (LRP1) Apolipoprotein E
Online-ссылка:	http://link.springer.com/article/10.1186/s13024-018-0286-0
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