TAPBPR promotes editing of the HLA-B44 peptide repertoire, increasing the presentation of peptides containing a C-terminal tryptophan

Major histocompatibility complex class I (MHC-I) molecules play a key part in the adaptive immune response by presenting antigens to CD8+ T cells. The high degree of polymorphism in MHC-I leads to significant variation in their dependence on the components of the antigen processing and presentation...

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Hlavní autoři:	Aure Aflalo, Arwen F. Altenburg, Marcel Wacker, Esam Khanfar, Jens Bauer, Juliane S. Walz, Louise H. Boyle
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-10-01
Edice:	Frontiers in Immunology
Témata:	MHC HLA TAPBPR antigen presentation immunopeptidomics
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1685705/full
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