Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development

Background Accumulating evidence suggests that the C-C chemokine ligand 2 (CCL2, or monocyte chemoattractant protein 1) acts as a neuromodulator in the central nervous system through its binding to the C-C chemokine receptor 2 (CCR2). Notably, it is well established that the CCL2/CCR2 axis plays a k...

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Autori principali:	Valérie Bégin-Lavallée MSc, Élora Midavaine BS, Marc-André Dansereau PhD, Pascal Tétreault PhD, Jean-Michel Longpré PhD, Ashley M Jacobi BS, Scott D Rose PhD, Mark A Behlke MD, PhD, Nicolas Beaudet PhD, Philippe Sarret PhD
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	SAGE Publishing 2016-06-01
Serie:	Molecular Pain
Accesso online:	https://doi.org/10.1177/1744806916653969
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