From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models

Abstract Human 3D cell cultures, including spheroids and organoids, are essential biological models for translational pharmaceutical and biomedical research. However, their 3D analysis using 2D‐ matrix‐assisted laser desorption/ionization (MALDI) imaging‐based spatial metabolomics remains challengin...

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Principais autores:	Stefania Alexandra Iakab, Jonas Cordes, Thomas Enzlein, Florian Keller, Kevin Kastner, Theresa Mulholland, Björn Christian Fröhlich, Lars Gruber, James Lucas Cairns, Stefan Schmidt, Mathias Hafner, Richard Schneider, Johannes Betge, Frank Fischer, Julian Reichwald, Rüdiger Rudolf, Carsten Hopf
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2026-02-01
Series:	Advanced Science
Assuntos:	3D reconstruction cancer research mass spectrometry imaging patient‐derived organoid pharmaceutical R&D translational clinical research
Acceso en liña:	https://doi.org/10.1002/advs.202516098
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