Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

Piplartine (or Piperlongumine) is a natural alkaloid isolated from <i>Piper longum</i> L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis has not been examined. This study was performed to examine the an...

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Автори:	Chi-Han Huang, Shu-Chi Wang, I-Chen Chen, Yi-Ting Chen, Po-Len Liu, Shih-Hua Fang, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Po-Yen Lee, Tzu-Chieh Lin, Wei-Chung Cheng, Chia-Cheng Su, Hsin-En Wu, Yuan-Ru Chen, Chia-Yang Li
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2021-06-01
Серія:	Pharmaceuticals
Предмети:	piplartine macrophage inflammation NLRP3 inflammasome sepsis
Онлайн доступ:	https://www.mdpi.com/1424-8247/14/6/588
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