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Detecting fitness epistasis in recently admixed populations with genome-wide data

Abstract Background Fitness epistasis, the interaction effect of genes at different loci on fitness, makes an important contribution to adaptive evolution. Although fitness interaction evidence has been observed in model organisms, it is more difficult to detect and remains poorly understood in huma...

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Principais autores: Xumin Ni, Mengshi Zhou, Heming Wang, Karen Y. He, Uli Broeckel, Craig Hanis, Sharon Kardia, Susan Redline, Richard S. Cooper, Hua Tang, Xiaofeng Zhu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-07-01
coleção:BMC Genomics
Assuntos:
Fitness epistasis
Admixed population
Admixture linkage disequilibrium
Co-evolution
Diseases/traits
Acesso em linha:http://link.springer.com/article/10.1186/s12864-020-06874-7
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