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Chidamide enhances the sensitivity of gastric cancer to 5-fluorouracil chemotherapy by suppressing the HDAC3/HNF4A/TYMS axis

Abstract Gastric cancer (GC) is among the most common malignant tumors in China and leads in incidence across all cancer types. For over three decades, the standard treatment has been traditional chemotherapy, which often involves monotherapy with 5-fluorouracil (5-FU) or its combination with other...

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Autors principals: Xiaofei Zhang, Lei Shi, Yaping Gao, Chenyi Zhou, Xiyin Wang, Xiaonan Shi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2025-12-01
Col·lecció:Cell Death and Disease
Accés en línia:https://doi.org/10.1038/s41419-025-08247-y
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