Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice

Abstract Background Geranylgeranylacetone (GGA), an anti-ulcer drug widely used in Japan, has attracted interest because of its various therapeutic effects. Therefore, we investigated the effects of GGA on human hepatic stellate cells (HSCs) in vitro and in a mouse model of liver fibrosis. Methods L...

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主要な著者:	Takemasa Senoo, Ryu Sasaki, Yuko Akazawa, Tatsuki Ichikawa, Satoshi Miuma, Hisamitsu Miyaaki, Naota Taura, Kazuhiko Nakao
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2018-02-01
シリーズ:	BMC Gastroenterology
主題:	Geranylgeranylacetone Hepatic stellate cells Liver fibrosis Apoptosis
オンライン･アクセス:	http://link.springer.com/article/10.1186/s12876-018-0761-7
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