Aberrant signaling in tonsillar B cells producing pathogenic O-glycoforms of IgA1 in IgA nephropathy

IgA nephropathy (IgAN) is a mesangioproliferative glomerulonephritis characterized by IgA1-containing immune-complex deposits wherein IgA1 is enriched for galactose-deficient IgA1 (Gd-IgA1) glycoforms. IgAN pathogenesis involves mucosal immune system, as IgAN onset and activity are associated with i...

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Autori principali:	Koshi Yamada, Kei Ogiwara, Jan Novak, Yusuke Suzuki
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-01-01
Serie:	Frontiers in Immunology
Soggetti:	a proliferation-inducing ligand (APRIL) galactose-deficient IgA1 (Gd-IgA1) genome-wide association studies (GWAS) IgA nephropathy leukemia inhibitory factor (LIF) nasal-associated lymphoid tissue (NALT)
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1737992/full
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