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Extracellular Matrix Protein 1 Regulates Colorectal Cancer Cell Proliferative, Migratory, Invasive and Epithelial-Mesenchymal Transition Activities Through the PI3K/AKT/GSK3β/Snail Signaling Axis

In prior reports, extracellular matrix protein 1 (ECM1) upregulation has been reported in colorectal cancer (CRC) patient tumor tissues, and has been suggested to be related to the metastatic progression of CRC, although the underlying mechanisms have yet to be clarified. In this study, we found tha...

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Principais autores: Sirui Long, Jie Wang, Fanbin Weng, Debing Xiang, Guiyin Sun
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Oncology
Fag:
Extracellular matrix protein 1
colorectal cancer
metastasis
epithelial-mesenchymal transition
PI3K/AKT/GSK3β/Snail signaling pathway
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2022.889159/full
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