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Inflammation preservation strategy: reconciling pain control and disc resorption in lumbar disc herniation

Lumbar disc herniation (LDH) is a prevalent condition driven by inflammation, which mediates both radicular pain and spontaneous resorption of herniated material. Traditional anti-inflammatory therapies alleviate pain but may impede disc regression. We propose an Inflammation Preservation Strategy (...

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Main Authors: Guanyi Gong, Zheng Yan, Qilong Lai, Peijie You, Pengfei Yu, Xiaochun Li, Zhiqiang Wang, Shun Lin, Yuxiang Dai, Hong Jiang, Jintao Liu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2025-09-01
Series:Frontiers in Immunology
Subjects:
lumbar disc herniation
inflammation preservation strategy
macrophage polarization
disc resorption
precision immunomodulation
spontaneous resorption
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1653681/full
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