Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest.

HIV-1 Viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/stress checkpoint. Recently, we and several other groups showed that Vpr performs this activity by recruiting the DDB1-CUL4A (VPRBP) E3 ubiquitin ligase. While recruitment of this E3 ubiquitin...

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Hlavní autoři:	Jean-Philippe Belzile, Levon G Abrahamyan, Francine C A Gérard, Nicole Rougeau, Eric A Cohen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2010-09-01
Edice:	PLoS Pathogens
On-line přístup:	http://europepmc.org/articles/PMC2932712?pdf=render
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