Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

BACKGROUND AND METHODOLOGY: Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, 2-phenoxy-1,4-naphthoquinone) showed an ED(50) of 80 nM against Trypanosoma brucei rhodesiense, and a...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Simone Pieretti, Jurgen R Haanstra, Muriel Mazet, Remo Perozzo, Christian Bergamini, Federica Prati, Romana Fato, Giorgio Lenaz, Giovanni Capranico, Reto Brun, Barbara M Bakker, Paul A M Michels, Leonardo Scapozza, Maria Laura Bolognesi, Andrea Cavalli
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Public Library of Science (PLoS) 2013-01-01
Σειρά:	PLoS Neglected Tropical Diseases
Διαθέσιμο Online:	http://europepmc.org/articles/PMC3547856?pdf=render
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