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Hemoglobin resident in the lung epithelium is protective for smooth muscle soluble guanylate cyclase function

Hemoglobin (Hb) present in the lung epithelium is of unknown significance. However Hb being an nitric oxide (NO) scavenger can bind to NO and reduce its deleterious effects. Hence we postulated an NO scavenging role for this lung Hb. Doing transwell co-culture with bronchial epithelial cells, A549/1...

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Principais autores: Mamta P. Sumi, Blair Tupta, Sanjoy Roychowdhury, Suzy Comhair, Kewal Asosingh, Dennis J. Stuehr, Serpil C. Erzurum, Arnab Ghosh
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-07-01
Serier:Redox Biology
Fag:
Inflammation
Cell Signaling
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213231723001180
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