A mild and atom-efficient four-component cascade strategy for the construction of biologically relevant 4-hydroxyquinolin-2(1H)-one derivatives

A mild and atom-economical four-component cascade reaction has been developed, enabling the efficient and selective synthesis of previously inaccessible 4-hydroxyquinolin-2(1H)-one derivatives. Utilizing readily available 6-halo-4-hydroxyquinolinones, aromatic aldehydes, Meldrum’s acid, and alcohols...

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Bibliografiske detaljer

Principais autores:	Dmitrii A. Grishin, Kseniia I. Sharkovskaia, Ilya G. Kolmakov, Daria A. Ipatova, Rostislav A. Petrov, Nikolai D. Dagaev, Dmitry A. Skvortsov, Maria G. Khrenova, Valeriy V. Andreychev, Sergei A. Evteev, Yan A. Ivanenkov, Roman L. Antipin, Olga А. Dontsova, Elena K. Beloglazkina
Format:	Artigo
Sprog:	Inglês
Udgivet:	Beilstein-Institut 2026-02-01
Serier:	Beilstein Journal of Organic Chemistry
Fag:	antibacterial activity 4-hydroxyquinolin-2(1h)-one ʟ-proline catalysis meldrum’s acid michael addition multicomponent reaction
Online adgang:	https://doi.org/10.3762/bjoc.22.18
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