Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression

In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency. Androgen receptor splice variant‐7 (ARV7) is clinically the most relevant and has a dist...

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Главные авторы:	Jasper Van Goubergen, Miroslav Peřina, Florian Handle, Elisa Morales, Anika Kremer, Oliver Schmidt, Glen Kristiansen, Marcus V. Cronauer, Frédéric R. Santer
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2025-02-01
Серии:	Molecular Oncology
Предметы:	3′ untranslated region allele‐specific regulation androgen receptor splice variant 7 dual specificity protein kinase CLK2 serine/arginine‐family of splicing factors splicing inhibitors
Online-ссылка:	https://doi.org/10.1002/1878-0261.13728
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