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iNOS is a key mediator of anti-PD-1 melanoma therapy response

BackgroundInducible nitric oxide synthase (iNOS) and its product nitric oxide (NO) were historically linked to poor melanoma outcomes, yet recent evidence shows NO supports anti-tumor immunity. This study examines how iNOS shapes anti–PD-1 efficacy, particularly through interferon signaling.MethodsB...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Quang Tam Nguyen, Youngchul Kim, Thi Hong Nga Le, Saurabh Garg, Vishanna Balkaran, Trisha Bhathivi, Alejandra Chamizo, Christopher W. Dukes, Kimberly Ward, Andrew S. Brohl, Lilit Karapetyan, Nikhil I. Khushalani, Zeynep Eroglu, Ahmad A. Tarhini, James J. Mulé, Joseph Markowitz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2026-06-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
anti-PD-1
immunotherapy
iNOS
melanoma
nitric oxide
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1837275/full
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