STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke

Abstract Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. The engulfment of stressed synapses by microglia further contributes to the disruption of the surviving neuronal network and related brain function. Unfortunately, there...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Chaoran Wu, Shiwen Zhang, Hao Sun, Ao Li, Fengsheng Hou, Long Qi, Hong Liao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-04-01
Edice:	Journal of Neuroinflammation
Témata:	Ischemic stroke Microglia Synapse phagocytosis STING STAT1
On-line přístup:	https://doi.org/10.1186/s12974-024-03086-8
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!