HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation

The null allele HLA-C*04:09N differs from HLA-C*04:01 in a frameshift mutation within its cytoplasmic domain, resulting in translation of 32 additional amino acids that are assumed to prevent cell surface expression. However, we recently identified a multiple myeloma-reactive T-cell receptor (TCR)...

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Auteurs principaux:	Carlotta Welters, Marthe-Lina Welters, Serena Stadler, Lars Bullinger, Julian Strobel, Holger Hackstein, Arunraj Dhamodaran, Thomas Blankenstein, Leo Hansmann
Format:	Artigo
Langue:	Inglês
Publié:	Ferrata Storti Foundation 2023-09-01
Collection:	Haematologica
Accès en ligne:	https://haematologica.org/article/view/11285
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