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Quantitative measurements of α-synuclein seeds in CSF inform diagnosis of synucleinopathies

Diagnosing α-synucleinopathies and assessing target engagement in trials is hindered by the lack of reliable biomarkers. Here, we introduce a first-in-kind quantitative, highly sensitive, and disease-specific diagnostic assay, named Seeding Amplification ImmunoAssay (SAIA), developed and validated t...

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Príomhchruthaitheoirí: Ilham Y Abdi, Indulekha P Sudhakaran, Simona S Ghanem, Nishant N Vaikath, Nour Majbour, Yee Y Goh, Nirosen Vijiaratnam, Christine Girges, Vasilios C Constantinides, Elisabeth Kapaki, George P Paraskevas, Sandrina Weber, Gholam Adeli, Kostas Vekrellis, Daniel Erskine, Michele Hu, Thomas Foltynie, Henry Houlden, Laura Parkkinen, Wilma DJ van de Berg, Brit Mollenhauer, Michael G Schlossmacher, Omar MA El-Agnaf
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: SAGE Publishing 2025-12-01
Sraith:Journal of Parkinson’s Disease
Rochtain ar líne:https://doi.org/10.1177/1877718X251379292
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