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Crowding alone cannot account for cosolute effect on amyloid aggregation.

Amyloid fiber formation is a specific form of protein aggregation, often resulting from the misfolding of native proteins. Aimed at modeling the crowded environment of the cell, recent experiments showed a reduction in fibrillation halftimes for amyloid-forming peptides in the presence of cosolutes...

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Hlavní autoři: Shahar Sukenik, Regina Politi, Lior Ziserman, Dganit Danino, Assaf Friedler, Daniel Harries
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2011-01-01
Edice:PLoS ONE
On-line přístup:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21249221/?tool=EBI
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