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Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis

Human serum albumin (HSA) is efficiently taken up by cancer cells as a source of carbon and energy. In this study, we prepared a monomodified derivative of HSA covalently linked to an EDTA derivative and investigated its efficacy to shuttle weakly anti-proliferative EDTA associating ligands such as...

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Principais autores: Itzik Cooper, Orly Ravid, Daniel Rand, Dana Atrakchi, Chen Shemesh, Yael Bresler, Gili Ben-Nissan, Michal Sharon, Mati Fridkin, Yoram Shechter
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-09-01
Serier:Pharmaceutics
Fag:
albumin
conjugates
vanadium
cancer
prodrug
Online adgang:https://www.mdpi.com/1999-4923/13/10/1557
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