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Circulating CD8 T cells from patients with mild-to-moderate psoriasis are functionally impaired

BackgroundPsoriasis is a systemic, immune-mediated, inflammatory skin disease in which T cells have been found to play a significant role. The phenotypic and functional properties of circulating CD8 T cells in the pathogenesis of the disease are still ill-defined.ObjectiveThis study aimed to assess...

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Principais autores: Yiqiao Chen, Chiara Tontini, Isabella Tosi, Jonathan N. Barker, Paola Di Meglio, Christopher E. M. Griffiths, Rajia Bahri, Silvia Bulfone-Paus
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-05-01
Serier:Frontiers in Immunology
Fag:
flow cytometry
CD8 T cells
multiparametric analysis
unsupervised clustering
immunophenotyping
peripheral blood mononuclear cells
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1585378/full
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