Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2

<b>Background:</b> Several pre-clinical and clinical reports suggest that HIV-1 protease inhibitors, in addition to the antiretroviral properties, possess pleiotropic pharmacological effects including anticancer action. Therefore, we investigated the pro-apoptotic activity in tumor cells of two mole...

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Autori principali:	Roberta Rinaldi, Rocchina Miglionico, Ilaria Nigro, Rosarita D’Orsi, Lucia Chiummiento, Maria Funicello, Paolo Lupattelli, Ilaria Laurenzana, Alessandro Sgambato, Magnus Monné, Faustino Bisaccia, Maria Francesca Armentano
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-11-01
Serie:	Cells
Soggetti:	HIV-1 protease inhibitors apoptosis ER stress UPR proteasome autophagy
Accesso online:	https://www.mdpi.com/2073-4409/10/11/3052
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