Exploring the unique function of imprinting control centers in the PWS/AS-responsible region: finding from array-based methylation analysis in cases with variously sized microdeletions

Abstract Background Human 15q11–13 is responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) and includes several imprinted genes together with bipartite elements named AS-IC (imprinting center) and PWS-IC. These concertedly confer allele specificity on 15q11–13. Here, we report DNA...

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Detalhes bibliográficos

Principais autores:	Keiko Matsubara, Masatsune Itoh, Kenji Shimizu, Shinji Saito, Keisuke Enomoto, Kazuhiko Nakabayashi, Kenichiro Hata, Kenji Kurosawa, Tsutomu Ogata, Maki Fukami, Masayo Kagami
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-02-01
coleção:	Clinical Epigenetics
Assuntos:	15q11–13 Prader-Willi syndrome Angelman syndrome Genome-wide methylation study Deletion
Acesso em linha:	http://link.springer.com/article/10.1186/s13148-019-0633-1
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