The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia

Abstract Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresistant nature of epilepsy associated with FCD may be...

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Detalles Bibliográficos

Principais autores:	Anderson Brito da Silva, Jane Pennifold, Ben Henley, Koustav Chatterjee, David Bateman, Roger W. Whittaker, Abhijit Joshi, Hrishikesh Kumar, Claire Nicholson, Mark R. Baker, Stuart D. Greenhill, Richard Walsh, Stefano Seri, Roland S. G. Jones, Gavin L. Woodhall, Mark O. Cunningham
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2022-09-01
Series:	Epilepsia Open
Assuntos:	AMPA epilepsy focal cortical dysplasia glutamate perampanel
Acceso en liña:	https://doi.org/10.1002/epi4.12549
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