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Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis

Abstract Background FK506, a macrolide mainly with immunosuppressive activity, can be produced by various Streptomyces strains. However, one of the major challenges in the fermentation of FK506 is its insufficient production, resulting in high fermentation costs and environmental burdens. Herein, we...

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Principais autores: Qing-Bin Wu, Xiao-Ying Zhang, Xin-Ai Chen, Yong-Quan Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-08-01
Serier:Microbial Cell Factories
Fag:
Streptomyces tsukubaensis
FK506
Hyper-production
Metabolic engineering
Biosynthetic gene cluster refactoring
Regulatory circuits
Online adgang:https://doi.org/10.1186/s12934-021-01660-w
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