Dl-3-n-Butylphthalide Alleviates Behavioral and Cognitive Symptoms Via Modulating Mitochondrial Dynamics in the A53T-α-Synuclein Mouse Model of Parkinson’s Disease

BackgroundAggregation and neurotoxicity of the presynaptic protein α-synuclein and the progressive loss of nigral dopaminergic neurons are believed to be the key hallmarks of Parkinson’s disease (PD). A53T mutant α-synuclein causes early onset PD and more severe manifestations. A growing body of evi...

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Autors principals:	Huiying Li, Hongquan Wang, Ling Zhang, Manshi Wang, Yanfeng Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-05-01
Col·lecció:	Frontiers in Neuroscience
Matèries:	Dl-3-n-butylphthalide α-synuclein mitochondrial dynamics Parkinson’s disease behavior deficits cognitive symptoms
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnins.2021.647266/full
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