Histone deacetylase inhibition reduces cardiac Connexin43 expression and gap junction communication

Histone deactylase (HDAC) inhibitors are being investigated as novel therapies for cancer, inflammation, neurodegeneration, and heart failure. The effects of HDAC inhibitors on the functional expression of cardiac gap junctions (GJ) are essentially unknown. The purpose of this study was to determine...

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Detalhes bibliográficos

Principais autores:	Qin eXu, Xianming eLin, Laura eAndrews, Dakshesh ePatel, Paul D Lampe, Richard David Veenstra
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2013-04-01
coleção:	Frontiers in Pharmacology
Assuntos:	Gap Junctions Phosphorylation connexin43 connexin40 Trichostatin A vorinostat
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00044/full
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