The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas
Despite being in the same pathway, mutations of KRAS and BRAF in colorectal carcinomas (CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal transition (EMT) and is associated with worse progression in most carcinomas. Using samples from patients with CRC, mouse mo...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical investigation
2023-10-01
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| Schriftenreihe: | JCI Insight |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1172/jci.insight.164629 |
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