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Solution structure of the C-terminal domain of the measles virus V protein in its free form and mechanistic analysis of STAT2 targeting

ABSTRACT Viruses commonly evade the host antiviral interferon (IFN) response by targeting key components of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway, typically STAT1 and STAT2. Among the well-characterized viral IFN antagonists, measles virus (MeV), a memb...

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Principais autores: Kaho Morita, Nanaka Goda, Madoka Kimoto, Satomi Inaba-Inoue, Nana Yabuno, Aoi Sugiyama, Hiroyuki Kumeta, Toyoyuki Ose
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2025-10-01
coleção:Journal of Virology
Assuntos:
STAT transcription factors
immune evasion
innate immunity
measles
paramyxovirus
protein–protein interactions
Acesso em linha:https://journals.asm.org/doi/10.1128/jvi.00739-25
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