Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation
Abstract Polycystin-1 (PC-1) and PC-2 form a heteromeric ion channel complex that is abundantly expressed in primary cilia of renal epithelial cells. This complex functions as a non-selective cation channel, and mutations within the polycystin complex cause autosomal dominant polycystic kidney disea...
Salvato in:
| Autori principali: | , , , , , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2024-07-01
|
| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-024-50318-9 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|