Strong and early immune responses against SARS-CoV-2 in mice and rhesus macaques after BNT162b3 vaccination

Abstract We preclinically characterize BNT162b3, a nucleoside-modified mRNA-based coronavirus disease 2019 (COVID-19) vaccine encoding a trimerized, cell surface-tethered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD-foldon), formulated in lipid nano...

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Auteurs principaux:	Annette B. Vogel, Bonny G. Lui, Kristin Tompkins, Isis Kanevsky, Alexander Muik, Stefanie A. Krumm, Alptekin Güler, Mohan S. Maddur, Kerstin C. Walzer, Sonja Witzel, Fulvia Vascotto, Eliana Stanganello, Ayuko Ota-Setlik, Kimberly J. Cottingham, Omaira Allbritton, Jessica Keverne, Letícia Aragão-Santiago, Kena A. Swanson, Özlem Türeci, Uğur Şahin
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2026-01-01
Collection:	npj Vaccines
Accès en ligne:	https://doi.org/10.1038/s41541-025-01365-w
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