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Early-life gut microbiome maturity regulates blood–brain barrier and cognitive development

The gut microbiome is an emerging factor in the neurobiology of disease. Blood–brain barrier (BBB) integrity is essential for proper brain function. However, the role the initial microbiome plays in BBB and brain development is unclear. In this study, we colonized germ-free pregnant mice with human...

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Автори: Zachary M. Zemmel, Xiaobing Fan, Yueyue Yu, Erica Markiewicz, Hsiu-Ming Tsai, Lei Lu, Jessica C. Little, Ramanujam Ramaswamy, Bree Andrews, Erika C. Claud, Jing Lu
Формат: Artigo
Мова:Inglês
Опубліковано: Taylor & Francis Group 2025-12-01
Серія:Gut Microbes
Предмети:
blood–brain barrier
gut–brain axis
neurodevelopmental impairment
single-cell RNA sequencing
magnetic resonance imaging
shotgun metagenomics
Онлайн доступ:https://www.tandfonline.com/doi/10.1080/19490976.2025.2551879
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