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Targeting the FGF19/FGFR4 positive feedback loop to disrupt ERK-mediated tumor progression in head and neck cancer

Abstract Background Head and neck cancer (HNC) is a biologically heterogeneous malignancy with limited actionable therapeutic targets. The fibroblast growth factor receptor (FGFR) family comprises receptor tyrosine kinases implicated in tumor progression; however, their specific roles in HNC remain...

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Principais autores: Yi-Fang Yang, Pei-Lun Yu, Chih-Yu Chou, Yu-Hsuan Lin
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Journal of Translational Medicine
Fag:
FGFR4
Head and neck cancer
ERK signaling
Chemoresistance
Feedback signaling
Metastasis
Online adgang:https://doi.org/10.1186/s12967-026-07999-1
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