HELQ upregulates PARP1 to drive platinum resistance and predict therapeutic response in ovarian cancer

POLQ-like helicase (HELQ), an evolutionarily conserved 3'-5′ DNA helicase, is markedly overexpressed in platinum-resistant ovarian cancer (OC), which is correlated with a poor prognosis. However, the mechanisms linking HELQ with resistance to platinum-based chemotherapy remain unkonwn. Our study pre...

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Detalhes bibliográficos

Principais autores:	Shuran Tan, Fang Zhu, Yi Li, Xinxin Wen, Siyu Yang, Zexi Liao, Xuerui Duan, Di Xiao, Yu Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-07-01
coleção:	Translational Oncology
Assuntos:	Ovarian carcinoma DNA helicase HELQ Platinum resistance PARP inhibitors
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1936523325001470
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