VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug resistance (MDR). VS-4718, a tyrosine kinase inhibitor targeting focal adhesion kinase (FAK) with a potential anticancer effect, is currently evaluated in clinical trials. In...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Ning Ji, Yuqi Yang, Chao-Yun Cai, Zi-Ning Lei, Jing-Quan Wang, Pranav Gupta, Qiu-Xu Teng, Zhe-Sheng Chen, Dexin Kong, Dong-Hua Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2018-10-01
Edice:	Frontiers in Pharmacology
Témata:	VS-4718 multidrug resistance (MDR) ATP-binding cassette (ABC) transporter P-glycoprotein (P-gp/ABCB1) breast cancer resistance protein (BCRP/ABCG2)
On-line přístup:	https://www.frontiersin.org/article/10.3389/fphar.2018.01236/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!