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HCN2 deficiency correlates with memory deficits and hyperexcitability of dCA1 pyramidal neurons in Alzheimer’s disease

Abstract Background Abnormal excitability of hippocampal neurons may lead to dysfunction of neural circuits and then causes cognitive impairments in Alzheimer’s disease (AD). However, the underlying mechanisms remain to be fully elucidated. Methods Electrophysiology was performed to examine the intr...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Xiaoqin Zhang, Yiping Zhang, Ting Zhang, Jing Wang, Chang Liu, Qing Shang, Xiaojie Wei, Huaqiang Zhu, Haowei Shen, Binggui Sun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMC 2025-02-01
Saila:Alzheimer’s Research & Therapy
Gaiak:
Sarrera elektronikoa:https://doi.org/10.1186/s13195-025-01704-y
Etiketak: Etiketa erantsi
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