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Impact of myeloperoxidase-LDL interactions on enzyme activity and subsequent posttranslational oxidative modifications of apoB-100

Oxidation of LDL by the myeloperoxidase (MPO)-H2O2-chloride system is a key event in the development of atherosclerosis. The present study aimed at investigating the interaction of MPO with native and modified LDL and at revealing posttranslational modifications on apoB-100 (the unique apolipoprotei...

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Main Authors: Cédric Delporte, Karim Zouaoui Boudjeltia, Caroline Noyon, Paul G. Furtmüller, Vincent Nuyens, Marie-Christine Slomianny, Philippe Madhoun, Jean-Marc Desmet, Pierre Raynal, Damien Dufour, Chintan N. Koyani, Florence Reyé, Alexandre Rousseau, Michel Vanhaeverbeek, Jean Ducobu, Jean-Claude Michalski, Jean Nève, Luc Vanhamme, Christian Obinger, Ernst Malle, Pierre Van Antwerpen
Format: Artigo
Language:Inglês
Published: Elsevier 2014-04-01
Series:Journal of Lipid Research
Subjects:
inflammation
myeloperoxidase activity
hypochlorous acid
3-chlorotyrosine
epitope mapping
low density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752037663X
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