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Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice

Transgenic mice overexpressing human tau with the P301L mutation develop neurofibrillary tangles, extensive gliosis, adult-onset motor abnormalities, and neuronal loss in affected brain regions. We investigated the mechanism of neuronal cell death in this model of tauopathy. There was no evidence of...

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Auteurs principaux: Cindy Zehr, Jada Lewis, Eileen McGowan, Julia Crook, Wen-Lang Lin, Kate Godwin, Joshua Knight, Dennis W Dickson, Mike Hutton
Format: Artigo
Langue:Inglês
Publié: Elsevier 2004-04-01
Collection:Neurobiology of Disease
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Accès en ligne:http://www.sciencedirect.com/science/article/pii/S0969996103002857
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