Targeted NMDA receptor knockdown in recall‐activated neuronal ensembles impairs remote fear extinction

Abstract Fear extinction training in rodents decreases fear responses, providing a model for the development of post-traumatic stress disorder therapeutics. Fear memory recall reactivates the consolidated fear memory trace across multiple brain regions, and several studies have suggested that these...

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Detalhes bibliográficos

Principais autores:	Yongmin Sung, Dae Hee Han, Junhyuk Kim, Pojeong Park, Bong-Kiun Kaang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-04-01
coleção:	Molecular Brain
Assuntos:	Remote fear memory extinction Recall-activated neurons N-methyl-d-aspartate receptors Clustered regularly interspaced short palindromic repeats (CRISPR)
Acesso em linha:	https://doi.org/10.1186/s13041-025-01203-z
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