In vitro evaluation of Verteporfin and exploration of TEAD palmitoylation inhibition in Piezo1–YAP/TAZ signaling and ECM remodeling

Abstract Fibrosis is characterized by excessive extracellular matrix (ECM) deposition driven by mechanical stress, yet the underlying molecular mechanisms remain incompletely understood. To investigate whether mechanical stress–induced ECM remodeling is mediated by YAP/TAZ–TEAD signaling and whether...

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Hauptverfasser:	Zhuang Xiaojun, Qiyong Chen, Shaoqiang Liu, Boling Liu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-12-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Verteporfin TEAD palmitoylation inhibitor Fibrotic ECM remodeling Mechanical stress YAP/TAZ Intervertebral disc degeneration
Online-Zugang:	https://doi.org/10.1038/s41598-025-28960-0
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