Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor

Progression to AD is preceded by elevated levels of 2,4-dihydroxybutanoic acid (2,4-DHB), implicating hypoxia in early pathogenesis. Since hypoxia may play a role in multiple CNS disorders, we investigated serum metabolite profiles across three disorders, AD, Normal Pressure Hydrocephalus (NPH) and...

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Bibliografske podrobnosti

Principais autores:	Matej Orešič, Gabriella Anderson, Ismo Mattila, Manoucher Manoucheri, Hilkka Soininen, Tuulia Hyötyläinen, Cherlynn Basignani
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2018-01-01
Serija:	Frontiers in Neuroscience
Teme:	Alzheimer's disease brain tumor hypoxia metabolomics normal pressure hydrocephalus
Online dostop:	http://journal.frontiersin.org/article/10.3389/fnins.2017.00747/full
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