Evolutionary insights and structural characterization guide the development of RAG1/RAG2-deficient swine models for immunological research

IntroductionDefects in RAG1/RAG2-mediated V(D)J recombination cause severe combined immunodeficiency (SCID), a disorder characterized by the absence of mature T and B lymphocytes resulting from impaired antigen receptor gene rearrangement. Although evolutionary analyses demonstrate strong conservati...

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Bibliographic Details

Main Authors:	Rui Zhang, Yunpeng Wu, Tianqi Sun, Tianqi Luan, Yanling Ren, Yilin Zhang, Lihao Lin, Teng Meng, Jin Wang, Yefeng Qiu
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-03-01
Series:	Frontiers in Immunology
Subjects:	CRISPR/Cas9 evolutionary characteristics immunodeficient pig models protein docking RAG1/RAG2 tertiary structural modeling
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1757508/full
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