PKC–NF-κB are involved in CCL2-induced Nav1.8 expression and channel function in dorsal root ganglion neurons

CCL2 [chemokine (C–C motif) ligand 2] contributes to the inflammation-induced neuropathic pain through activating VGSC (voltage-gated sodium channel)-mediated nerve impulse conduction, but the underlying mechanism is currently unknown. Our study aimed to investigate whether PKC (protein kinase C)–NF...

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Ngā kaituhi matua:	Rui Zhao, Guo‑Xian Pei, Rui Cong, Hang Zhang, Cheng‑Wu Zang, Tong Tian
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Portland Press 2014-06-01
Rangatū:	Bioscience Reports
Ngā marau:	CCL2 CCR2 dorsal root ganglion (DRG) Nav1.8 nociception PKC
Urunga tuihono:	http://www.bioscirep.org/bsr/034/e111/bsr034e111.htm
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!