NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

ABSTRACT Metabolic reprogramming is a hallmark of cancer that promotes tumor progression and immune evasion. Here, we identify a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma (ESCC) that facilitates tumor growth and suppresses antitumor immunity. Mechanistically, N...

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Hlavní autoři:	Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-05-01
Edice:	Advanced Science
Témata:	esophageal squamous cell carcinoma histone lactylation immune evasion lactate NIPAL1
On-line přístup:	https://doi.org/10.1002/advs.202520055
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