Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics
Abstract Background Oxycodone, a widely used opioid analgesic, has an unbound brain-to-plasma concentration ratio (Kp,uu) greater than unity, indicating active uptake across brain barriers associated with the putative proton-coupled organic cation (H+/OC) antiporter system. With this study, we aimed...
Sparad:
| Huvudupphov: | , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
BMC
2024-12-01
|
| Serie: | Fluids and Barriers of the CNS |
| Ämnen: | |
| Länkar: | https://doi.org/10.1186/s12987-024-00598-6 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|