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Structure-Aided Design of a LuxR-Type Quorum Sensing SuFEx-Based Potential Inhibitor: Covalent or Competitive Inhibition?

New <i>N</i>-benzoyl-<span style="font-variant: small-caps;">l</span>-homoserine lactone derivatives bearing a <i>meta</i>-fluorosulfonyl or a <i>meta</i>-methylsulfonyl group have been designed, synthesized and evaluated as quorum sensing (QS) inhibitors. Docking simulations involving the structure...

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Príomhchruthaitheoirí: Laurent Soulère, Sylvie Reverchon, Jessica Baude, Emmanuel Chefdeville, Antoine Vauchez, Yves Queneau, William Nasser
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: MDPI AG 2026-02-01
Sraith:Biomolecules
Ábhair:
Rochtain ar líne:https://www.mdpi.com/2218-273X/16/2/305
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