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Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39

Pyrimidine nucleotides play an important role in the biosynthesis of activated nucleotide sugars (NDP-sugars). NDP-sugars are the precursors of structural polysaccharides in bacteria, including capsule, which is a major virulence factor of the human pathogen S. pneumoniae. In this work, we identifie...

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Autori principali: Sandra M. Carvalho, Tomas G. Kloosterman, Irfan Manzoor, José Caldas, Susana Vinga, Jan Martinussen, Lígia M. Saraiva, Oscar P. Kuipers, Ana R. Neves
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018-03-01
Serie:Frontiers in Microbiology
Soggetti:
Streptococcus pneumoniae
spontaneous mutations
uracil metabolism
capsule biosynthesis
gene expression
Accesso online:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00321/full
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